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Details for Product No. ABIN121278

HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody

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Synonyms OMI, PARK13, PRSS25, Omi, mnd2, Prss25, AI481710, CG8464, DmHtrA2, Dmel\\CG8464, HtrA2/Omi, dOmi, domi, htrA2, omi, HTRA2
»Alternatives AA 335-350
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN121278
Quantity 0.1 mg
489.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide containing amino acids 335-350 of human Omi/HtrA2
Clone 196C429
Isotype IgG1
Purification Protein G chromatography
Alternative Name HTRA2 / PRSS25
Background The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
UniProt O43464
Application Notes Western blot: 2 - 3 ug/ml. Immunohistochemistry on paraffin sections. Recommended Positive Control: Jurkat or HL-60 cell lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05 % sodium azide and 0.2 % gelatin
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Deveraux, Reed: "IAP family proteins--suppressors of apoptosis." in: Genes & development, Vol. 13, Issue 3, pp. 239-52, 1999 (PubMed).

Reed, Bischoff: "BIRinging chromosomes through cell division--and survivin' the experience." in: Cell, Vol. 102, Issue 5, pp. 545-8, 2000 (PubMed).

Hegde, Srinivasula, Zhang et al.: "Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 432-8, 2002 (PubMed).

Alternatives for antigen "HtrA Serine Peptidase 2 (HTRA2)", type "Antibodies"
Hosts (82), (32)
Reactivities (118), (37), (35), (13), (13), (1)
Applications (88), (57), (32), (26), (10), (10), (6), (4), (2), (2), (2), (2), (2), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (5), (5), (4), (4), (3), (3), (2), (1), (1)