Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN121283

Tumor Protein P73 (TP73) (AA 2-13) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms P73, TAp73, zp73theta, TP73, tp73
Epitope
»Alternatives AA 2-13
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN121283
Quantity 0.1 mg
Price
489.50 $   Plus shipping costs $45.00
Shipping to
Availability Discontinued
Immunogen Peptide corresponding to amino acid residues 2-13 of human dNp73. AA Sequence: LYVGDPARHLAT
Clone 38C674-2
Isotype IgG1
Purification Protein G Chromatography.
Background P73 was identified as a long-lost cousin of tumor suppressor protein, p53 (1). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (2). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (3). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy- terminal region of p73 may be important for the functions of this protein (4). Recently, Yang et al. (2000) have cloned a p73 variant that lacks an amino-terminal transactivation domain, called deltaNp73 (5). The dNp73 message is transcribed from an alternative promoter located in intron 3. Alternate Names: Gamma Np73.
UniProt O15350
Application Notes Western blotting: 1-3 ug/ml. Immunohistochemistry on paraffin sections: 1/2000. ChIP: 5 ug. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Kaghad, Bonnet, Yang et al.: "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers." in: Cell, Vol. 90, Issue 4, pp. 809-19, 1997 (PubMed).

Ueda, Hijikata, Takagi et al.: "New p73 variants with altered C-terminal structures have varied transcriptional activities." in: Oncogene, Vol. 18, Issue 35, pp. 4993-8, 1999 (PubMed).

Yang, Walker, Bronson et al.: "p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours." in: Nature, Vol. 404, Issue 6773, pp. 99-103, 2000 (PubMed).

Levrero, De Laurenzi, Costanzo et al.: "The p53/p63/p73 family of transcription factors: overlapping and distinct functions." in: Journal of cell science, Vol. 113 ( Pt 10), pp. 1661-70, 2000 (PubMed).

Alternatives for antigen "Tumor Protein P73 (TP73)", type "Antibodies"
Hosts (72), (32)
Reactivities (97), (38), (25), (8), (2)
Applications (92), (32), (27), (23), (12), (10), (9), (8), (7), (4), (3), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (9), (8), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Beacon