Tumor Protein P73 (TP73) (AA 2-13) antibody

Details for Product No. ABIN121283
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Antigen
Epitope
AA 2-13
(38), (13), (10), (7), (5), (5), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(158), (68), (46), (8), (2)
Host
Mouse
(139), (26)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(142), (35), (35), (30), (26), (20), (20), (8), (6), (6), (5), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN121283
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Immunogen Peptide corresponding to amino acid residues 2-13 of human dNp73. AA Sequence: LYVGDPARHLAT
Clone 38C674-2
Isotype IgG1
Purification Protein G Chromatography.
Background P73 was identified as a long-lost cousin of tumor suppressor protein, p53 (1). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (2). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (3). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy- terminal region of p73 may be important for the functions of this protein (4). Recently, Yang et al. (2000) have cloned a p73 variant that lacks an amino-terminal transactivation domain, called deltaNp73 (5). The dNp73 message is transcribed from an alternative promoter located in intron 3. Alternate Names: Gamma Np73.
UniProt O15350
Application Notes Western blotting: 1-3 ug/ml. Immunohistochemistry on paraffin sections: 1/2000. ChIP: 5 ug. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Protein P73 (TP73) (AA 2-13) antibody Western blot analysis for p73N using ABIN121283 at 1 ug/ml dilution in a cell line transfected with p73N cDNA.
General Kaghad, Bonnet, Yang et al.: "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers." in: Cell, Vol. 90, Issue 4, pp. 809-19, 1997 (PubMed).

Ueda, Hijikata, Takagi et al.: "New p73 variants with altered C-terminal structures have varied transcriptional activities." in: Oncogene, Vol. 18, Issue 35, pp. 4993-8, 1999 (PubMed).

Yang, Walker, Bronson et al.: "p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours." in: Nature, Vol. 404, Issue 6773, pp. 99-103, 2000 (PubMed).

Levrero, De Laurenzi, Costanzo et al.: "The p53/p63/p73 family of transcription factors: overlapping and distinct functions." in: Journal of cell science, Vol. 113 ( Pt 10), pp. 1661-70, 2000 (PubMed).

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