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Details for Product No. ABIN121285

Peptidoglycan Recognition Protein 3 (PGLYRP3) (AA 178-193) antibody

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Antigen
Synonyms PGRP-Ialpha, PGRPIA, Gm420, PGLYRP3
Epitope
»Alternatives AA 178-193
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN121285
Quantity 0.2 mL
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH-conjugated synthetic peptide corresponding to amino acids 178-193 of human PGRP-1a
Clone 187C434
Isotype IgG1
Purification Purified
Alternative Name PGLYRP3
Background Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia , and PGRP-Iß) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
UniProt Q96LB9
Application Notes Western blot: (1/500-1/1,000). Flow Cytometry: (see Uehara et al, 2005). Immunocytochemistry (cell surface): (see Uehara et al, 2005). Recommended positive control: human brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 0.05 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Schleifer, Kandler: "Peptidoglycan types of bacterial cell walls and their taxonomic implications." in: Bacteriological reviews, Vol. 36, Issue 4, pp. 407-77, 1973 (PubMed).

Liu, Gelius, Liu et al.: "Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth." in: The Journal of biological chemistry, Vol. 275, Issue 32, pp. 24490-9, 2000 (PubMed).

Liu, Xu, Gupta et al.: "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 34686-94, 2001 (PubMed).

Alternatives for antigen "Peptidoglycan Recognition Protein 3 (PGLYRP3)", type "Antibodies"
Hosts (6), (4)
Reactivities (11), (2), (2)
Applications (10), (4), (4), (3), (2), (1), (1), (1)
Epitopes (2), (2), (1)
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