TNF Receptor-Associated Factor 2 (TRAF2) (AA 205-222) antibody

Details for Product No. ABIN121316
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Antigen
Epitope
AA 205-222
(23), (13), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(98), (45), (38), (4)
Host
Mouse
(76), (19), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(89), (45), (32), (26), (16), (10), (8), (8), (5), (4), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN121316
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Immunogen Fusion protein corresponding to amino acids 205 to 222 of human TRAF2
Clone 33A1293
Isotype IgG1
Purification Protein G chromatography
Alternative Name TRAF2 / TRAP3
Background Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF2 is a 502-amino acid protein. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-kB activation, where as interaction with TNFR is mediated through C-terminus domain (5,6). Distinct domains in the N- and -C termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP). TRAF2 is involved in cellular resistant to TNF-induced apoptosis. TRAF-2 deficient mice appeared normal at birth, however, they die prematurely, probably due to atrophy of thymus, spleen, muscle mass and lack of TRAF-2's cytoprotective role.
UniProt Q12933
Application Notes Western blot analysis: 2.0 ug/ml. Recommended positive control: HeLa (a ~57 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2 % gelatin and 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 205-222) antibody Western blot analysis of 30 ug of HeLa cell lysate with ABIN121316 at 2ug/ml.
General Takeuchi: "[Purification and characterization of alkaline phosphatase obtained from bovine periodontal ligament]" in: Kanagawa shigaku. The Journal of the Kanagawa Odontological Society, Vol. 24, Issue 4, pp. 702-15, 1992 (PubMed).

Cheng, Cleary, Ye et al.: "Involvement of CRAF1, a relative of TRAF, in CD40 signaling." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1494-8, 1995 (PubMed).

Rothe, Wong, Henzel et al.: "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor." in: Cell, Vol. 78, Issue 4, pp. 681-92, 1994 (PubMed).

Cao, Xiong, Takeuchi et al.: "TRAF6 is a signal transducer for interleukin-1." in: Nature, Vol. 383, Issue 6599, pp. 443-6, 1996 (PubMed).

Park, Burkitt, Villa et al.: "Structural basis for self-association and receptor recognition of human TRAF2." in: Nature, Vol. 398, Issue 6727, pp. 533-8, 1999 (PubMed).

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