TNF Receptor-Associated Factor 5 (TRAF5) (AA 77-186) antibody

Details for Product No. ABIN121317
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Antigen
Epitope
AA 77-186
(4), (3), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(22), (6), (4), (1)
Host
Mouse
(16), (8)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(24), (6), (6), (5), (4), (4), (4), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN121317
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Immunogen Fusion protein corresponding to amino acids 77 to 186 of human TRAF5
Clone 55A219
Isotype IgG1
Purification Protein G Chromatography
Alternative Name TRAF5 / RNF84
Background Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40- CD27 mediated lymhocyte activation (5).
UniProt O00463
Application Notes Western blot: 2.0 ug/ml. Recommended positive control: HeLa. In HeLa, a ~64 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-TNF Receptor-Associated Factor 5 (TRAF5) (AA 77-186) antibody Western blot analysis of TRAF5 using ABIN121317 at 2 ug/ml dilution against 10 ug of HeLa cell lysate.
General Cheng, Cleary, Ye et al.: "Involvement of CRAF1, a relative of TRAF, in CD40 signaling." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1494-8, 1995 (PubMed).

Rothe, Wong, Henzel et al.: "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor." in: Cell, Vol. 78, Issue 4, pp. 681-92, 1994 (PubMed).

Cao, Xiong, Takeuchi et al.: "TRAF6 is a signal transducer for interleukin-1." in: Nature, Vol. 383, Issue 6599, pp. 443-6, 1996 (PubMed).

Nakano, Sakon, Koseki et al.: "Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 17, pp. 9803-8, 1999 (PubMed).

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