Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317), (N-Term) antibody

Details for Product No. ABIN121319
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Antigen
Epitope
AA 1-317, N-Term
(9), (9), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(115), (99), (32), (25), (13), (1), (1)
Host
Mouse
(119), (25), (21), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(23), (8), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(128), (81), (34), (26), (24), (20), (15), (11), (10), (6), (5), (3), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN121319
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Immunogen Bacterially expressed fusion protein containing amino acid residues 1-317 of mouse TRANCE
Clone 12A668
Isotype IgG1
Purification Protein G Chromatography
Alternative Name CD254 / RANKL
Background TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).
UniProt O14788
Application Notes Western blot analysis: 1.0 - 2.0 ug/ml. Immunohistochemistry on paraffin embedded sections. Recommended Positive Control: activated T cells or RAW. This mAb does not work for flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317), (N-Term) antibody Western blot analysis of TRANCE/RANKL in transfected cells. A single protein band of approximate mol. wt. of 35 kDa was detected.
General Anderson, Maraskovsky, Billingsley et al.: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, 1997 (PubMed).

Wong, Josien, Lee et al.: "TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor." in: The Journal of experimental medicine, Vol. 186, Issue 12, pp. 2075-80, 1998 (PubMed).

Kong, Yoshida, Sarosi et al.: "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis." in: Nature, Vol. 397, Issue 6717, pp. 315-23, 1999 (PubMed).

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