Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317), (N-Term) antibody

Details for Product No. ABIN121320
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Epitope
AA 1-317, N-Term
(9), (9), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(115), (99), (32), (25), (13), (1), (1)
Host
Mouse
(119), (25), (21), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(23), (8), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Flow Cytometry (FACS)
(128), (81), (34), (26), (24), (20), (15), (11), (10), (6), (5), (3), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121320
500.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A bacterially expressed fusion protein containing amino acid residues 1-317 of mouse TRANCE
Clone 12A380
Isotype IgG1
Purification Protein G Chromatography.
Alternative Name CD254 / RANKL
Background TRANCE is a member of tumor necrosis factor family. TRANCE or RANKL has been implicated in interactions between T cells and dendritic cells (ref. 4-5). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (ref. 4). TRANCE/RANKL is also important in T- and B-cell maturation (ref. 3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (ref. 1,2). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (ref. 3). Alternate Names: RANKL (receptor activator of NF-kB (RANK) ligand), OPGL, ODF.
UniProt O14788
Application Notes Western blotting (4-6 ug/ml). Immunohistochemistry on frozen sections (ref. 6). Flow cytometry (Cell Surface, ref. 6). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317), (N-Term) antibody Western blot analysis of TRANCE in transfected cells using SM7110 at 5 ug/ml.
General Anderson, Maraskovsky, Billingsley et al.: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, 1997 (PubMed).

Wong, Josien, Lee et al.: "TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor." in: The Journal of experimental medicine, Vol. 186, Issue 12, pp. 2075-80, 1998 (PubMed).

Lacey, Timms, Tan et al.: "Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation." in: Cell, Vol. 93, Issue 2, pp. 165-76, 1998 (PubMed).

Kong, Yoshida, Sarosi et al.: "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis." in: Nature, Vol. 397, Issue 6717, pp. 315-23, 1999 (PubMed).

Hsu, Lacey, Dunstan et al.: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

Validation Images
Did you look for something else?
back to top