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Details for Product No. ABIN121321

Telomeric Repeat Binding Factor 2 (TERF2) antibody

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Antigen
Synonyms TRF2, TRBF2, trf2, TERF2
Reactivity
»Alternatives Deer, Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN121321
Quantity 0.1 mg
Price
489.50 $   Plus shipping costs $45.00
Shipping to
Availability Discontinued
Immunogen Baculovirus expressed whole length TRF2 protein was used for immunizing and splenocytes used to generate the hybridoma clone
Clone 4A794-15
Isotype IgG1
Purification Protein G chromatography
Alternative Name TERF2
Background TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3).
UniProt Q15554
Research Area DNA/RNA, Cell Cycle, Enzymes
Application Notes Western blot: 2.0 ug/ml. Immunoprecipitation: 2 ug/1X10e6 cells. ELISA: 2 ug/ml. Immunocytochemistry/Immunofluorescence. Immunohistochemistry on frozen sections: 5 ug/ml. Recommended positive control: HL60 (The antibody recognizes distinct doublet bands of approximate size 66 kDa corresponding to the molecular size of huTRF2 by western blot analysis against lysates from most human cell lines). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05 % BSA and 0.05 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Broccoli, Smogorzewska, Chong et al.: "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2." in: Nature genetics, Vol. 17, Issue 2, pp. 231-5, 1997 (PubMed).

Bradshaw, Stavropoulos, Meyn: "Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage." in: Nature genetics, Vol. 37, Issue 2, pp. 193-7, 2005 (PubMed).

Alternatives for antigen "Telomeric Repeat Binding Factor 2 (TERF2)", type "Antibodies"
Hosts (26), (11), (10)
Reactivities (44), (14), (8), (2), (2), (2), (2), (1)
Applications (42), (20), (18), (13), (12), (10), (10), (4), (3), (2), (2), (1), (1), (1)
Conjugates (2), (2), (2), (1), (1)
Epitopes (6), (2), (1), (1), (1), (1), (1), (1), (1)
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