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Details for Product No. ABIN121322

Toll-Like Receptor 6 (TLR6) (AA 408-424) antibody

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Antigen
Synonyms CD286, TLR-6, TLR1, TLR16
Epitope
»Alternatives AA 408-424
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN121322
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to amino acids 408-424 of human TRL6
Clone 86B1153
Isotype IgG1
Purification Protein G Chromatography.
Alternative Name CD286 / TLR6
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity at the amino acid level. Human TLR6 consists of a predicted 807 amino acids with a molecular weight of approximately 92 kDa (3). Human and mouse TLR6 share an amino acid identity of 73%. TLR6 activates both NF-kB and c-Jun N- terminal Kinase (JNK). The amino acids in the cytoplasmic domain of IL-1 receptor, which are critical for NF-kB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6 (4). TLR6 is predominantly expressed in spleen, thymus, ovary, and lung (3). Alternate Names: TLR-6, Toll-like Receptor 6, FocusOn004.
UniProt Q9Y2C9
Research Area Signaling, Immunology, Inflammation
Application Notes Flow cytometry (Intracellular): 3-5 ug / 10e6 cells. Ramos cells can be used as a positive control. Flow Cytometry (Cell surface): see Wong et al. (2007) for details. Immunohistochemistry on Paraffin Sections: 5 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% Sodium Azide as preservative and 0.05% BSA as stabilizer.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Takeuchi, Kawai, Sanjo et al.: "TLR6: A novel member of an expanding toll-like receptor family." in: Gene, Vol. 231, Issue 1-2, pp. 59-65, 1999 (PubMed).

Hajjar, OMahony, Ozinsky et al.: "Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 15-9, 2001 (PubMed).

Alternatives for antigen "Toll-Like Receptor 6 (TLR6)", type "Antibodies"
Hosts (85), (38), (8)
Reactivities (121), (42), (18), (17), (1)
Applications (68), (45), (44), (30), (19), (16), (14), (10), (2), (2), (1), (1), (1)
Conjugates (9), (8), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (8), (8), (8), (5), (5), (5), (2), (2), (2), (2), (2), (1), (1)
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