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DFFA antibody (DNA Fragmentation Factor, 45kDa, alpha Polypeptide) (AA 2-21)

Details for Product anti-DFFA Antibody No. ABIN121553, Supplier: Login to see
Antigen
  • DFFA
  • DFF-45
  • DFF1
  • ICAD
  • A330085O09Rik
  • DFF35
  • Dff45
  • ICAD-L
  • ICAD-S
Alternatives
anti-Mouse (Murine) DFFA antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 2-21, N-Term
41
29
19
16
14
13
13
10
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
168
77
32
1
1
Host
Rabbit
194
37
2
Clonality
Polyclonal
Conjugate
This DFFA antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
191
73
41
28
26
23
15
11
6
4
4
3
2
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to amino acids 2-21 of mouse ICAD
Isotype IgG
Specificity This antibody reacts to ICAD at C-term.
Purification Afinity Chromatography
Alternative Name DFFA / ICAD (DFFA Antibody Abstract)
Background ICAD (Inhibitor of Caspase-Activated Dnase) is the murine homologue of human DFF-45. ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus.Synonyms: DFF-45, DFF1, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, Inhibitor of CAD
UniProt O54786
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western blot: 1/1000, this antibody recognises a 45 kD band in Western blots.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Wyllie: "Apoptosis. An endonuclease at last." in: Nature, Vol. 391, Issue 6662, pp. 20-1, 1998 (PubMed).