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Details for Product No. ABIN121554

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (C-Term), (AA 116-131) antibody

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Antigen
Synonyms NACP, PARK1, PARK4, PD1
Epitope
»Alternatives C-Term, AA 116-131
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN121554
Quantity 0.1 mL
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein
Purification Serum
Alternative Name Alpha-Synuclein / SNCA
Background The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinsons disease. The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimers disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewys bodies.
UniProt P37840
Research Area Neurology
Application Notes ELISA: 1/1000 vs immunising peptide. Immunohistochemistry on paraffin sections: 1/300, this product does not require protein digestion pre-treatment of paraffin sections, this product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Brain, Spinal Cord. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Containing 0.09% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Spillantini, Schmidt, Lee et al.: "Alpha-synuclein in Lewy bodies." in: Nature, Vol. 388, Issue 6645, pp. 839-40, 1997 (PubMed).

Gai, Power, Blumbergs et al.: "Multiple-system atrophy: a new alpha-synuclein disease?" in: Lancet, Vol. 352, Issue 9127, pp. 547-8, 1998 (PubMed).

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts (252), (93), (15), (13), (1)
Reactivities (356), (171), (148), (91), (87), (78), (24), (24), (2), (1), (1), (1)
Applications (237), (135), (92), (80), (60), (49), (22), (17), (13), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8)
Epitopes (36), (30), (25), (23), (20), (12), (9), (8), (8), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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