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Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) antibody

Antigen

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)
Clonality Polyclonal
Host
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
2 references available
Catalog no. ABIN121554
Quantity 0.1 ml
Price 429.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Alpha-Synuclein / SNCA
UniProt P37840
Immunogen Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein
Cross-Reactivity Human
Description The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinsons disease. The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimers disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewys bodies.
Specificity This antibody recognises human alpha-synuclein.

Application Details
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Application Notes ELISA: 1/1000 vs immunising peptide. Immunohistochemistry on paraffin sections: 1/300, this product does not require protein digestion pre-treatment of paraffin sections, this product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Brain, Spinal Cord. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Purification Serum
Buffer Containing 0.09% Sodium Azide
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Research Area Neurology
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Spillantini, Schmidt, Lee et al.: "Alpha-synuclein in Lewy bodies." in: Nature, Vol. 388, Issue 6645, pp. 839-40, 1997 (PubMed).

Gai, Power, Blumbergs et al.: "Multiple-system atrophy: a new alpha-synuclein disease?" in: Lancet, Vol. 352, Issue 9127, pp. 547-8, 1998 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts Rabbit (132), Mouse (60), Goat (14), Sheep (4), Rat (1)
Reactivities Human (197), Rat (Rattus) (83), Mouse (Murine) (75), Pig (Porcine) (43), Cow (Bovine) (41), Dog (Canine) (41), Horse (Equine) (38), Sheep (Ovine) (38), Guinea Pig (18)
Applications Western Blotting (WB) (130), ELISA (77), Immunofluorescence (IF) (73), Immunohistochemistry (IHC) (40), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (40), Immunoprecipitation (IP) (14), Immunohistochemistry (Fixed) (IHC (fx)) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Enzyme Immunoassay (EIA) (2), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (2), Radioimmunoassay (RIA) (2)
Conjugates Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), Biotin (5), PE,Cy5.5 (5), FITC (3), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes C-Term (21), pSer129 (17), pTyr133 (11), pTyr136 (11), pTyr125 (10), AA 61-95 (6), AA 1-140 (5), Internal Region (4), AA 108-120 (3), AA 116-131 (3), AA 111-131 (2), Tyr133 (2), pSer87 (2), AA 1-115 (1), AA 116-113 (1), AA 129-140 (1), pTyr215 (1)