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SNCA antibody (Synuclein, alpha) (AA 116-131)

Details for Product anti-SNCA Antibody No. ABIN121554, Supplier: Log in to see
Antigen
  • alphaSYN
  • LOC619283
  • MGC64356
  • NACP
  • PARK1
  • PARK4
  • PD1
  • snca
Epitope
AA 116-131, C-Term
62
47
41
39
35
35
13
12
12
11
8
6
6
5
5
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
536
212
207
16
14
11
11
8
4
2
2
2
1
1
1
Host
Goat
393
132
30
10
2
2
Clonality
Polyclonal
Conjugate
This SNCA antibody is un-conjugated
24
22
20
8
8
6
6
6
6
6
6
6
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
396
203
118
99
69
67
27
21
17
16
9
7
2
1
1
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein
Purification Serum
Alternative Name alpha-Synuclein / SNCA (SNCA Antibody Abstract)
Background The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinsons disease. The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimers disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewys bodies.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
UniProt P37840
Research Area Neurology
Application Notes ELISA: 1/1000 vs immunising peptide. Immunohistochemistry on paraffin sections: 1/300, this product does not require protein digestion pre-treatment of paraffin sections, this product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Brain, Spinal Cord.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Containing 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Gai, Power, Blumbergs, Blessing: "Multiple-system atrophy: a new alpha-synuclein disease?" in: Lancet (London, England), Vol. 352, Issue 9127, pp. 547-8, 1998

Spillantini, Schmidt, Lee, Trojanowski, Jakes, Goedert: "Alpha-synuclein in Lewy bodies." in: Nature, Vol. 388, Issue 6645, pp. 839-40, 1997