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Details for Product No. ABIN121675

SMAD, Mothers Against DPP Homolog 2 (SMAD2) antibody

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Antigen
Synonyms MADH2, madh2, fj43c06, wu:fj43c06, XSmad2, smad-2, JV18, JV18-1, MADR2, hMAD-2, hSMAD2, 7120426M23Rik, Madh2, Madr2, Smad-2, mMad2, jv18, Xmad2, madr2, hmad-2, hsmad2, jv18-1
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN121675
Quantity 0.1 mg
Price
599.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide SEIWGLSTPNTID derived from MADH2 protein sequence
Purification Affinity chromatography
Alternative Name SMAD2
Background This protein is a transcriptional modulator activated by TGF beta and may act as a tumour suppressor in colorectal carcinoma. It is found at high levels in skeletal muscle, heart and placenta. MADH2 exists in isoforms, a predominant long form and a short form missing the 30 amino acid exon 3. The short form shows DNA binding and higher transcriptional activation activity. Alternate Names: MADH2.
Research Area Signaling, Transcription Factors
Application Notes Western Blot: 1/200 - 1/500, this antibody detects bands of approximately 45kDa and 50kDa in HeLa cell lysates, a minimum incubation time of 1 hour is recommended with this antibody. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer TRIS buffered saline pH7.3 containing 0.02% Sodium Azide and 0.5% Bovine Serum Albumin
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Eppert, Scherer, Ozcelik et al.: "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma." in: Cell, Vol. 86, Issue 4, pp. 543-52, 1996 (PubMed).

Alternatives for antigen "SMAD, Mothers Against DPP Homolog 2 (SMAD2)", type "Antibodies"
Hosts (254), (31), (12)
Reactivities (291), (193), (189), (82), (77), (67), (13), (3), (3), (3), (2), (1), (1), (1), (1)
Applications (230), (117), (60), (54), (53), (44), (17), (13), (9), (6), (4), (3), (2), (1)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4)
Epitopes (34), (32), (27), (19), (18), (13), (13), (12), (8), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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