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Mdc1 (MDC1) (AA 1883-2089) antibody

Details for Product No. ABIN121711
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Antigen
Synonyms 6820401C03, AA413496, Nfbd1, mKIAA0170, NFBD1
Epitope
AA 1883-2089
(18), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(48), (32), (16), (12), (12), (12), (3), (1)
Host
Sheep
(39), (22), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(46), (27), (11), (10), (9), (7), (5), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121711
632.50 $
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Immunogen Recombinant MDC1 BRCT domains (aa 1883 - 2089)
Purification Serum
Alternative Name MDC1
Background Research suggest that MDC1 is involved in the early stages of response to DNA damage and may recruit other factor to sites of DNA damage. Alternate Names: Mediator of DNA Damage Checkpoint Protein 1.
UniProt Q14676
Research Area Chromatin and Nuclear Signaling, DNA/RNA, Chemokines
Application Notes ELISA: direct. Western Blot: 1:2000, this antibody detects 3 bands of approximately 250 kDa in HeLa and 293T cell lysates. Immunofluorescence: 1:500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Containing 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Goldberg, Stucki, Falck et al.: "MDC1 is required for the intra-S-phase DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 952-6, 2003 (PubMed).

Lou, Minter-Dykhouse, Wu et al.: "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways." in: Nature, Vol. 421, Issue 6926, pp. 957-61, 2003 (PubMed).

Stewart, Wang, Bignell et al.: "MDC1 is a mediator of the mammalian DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 961-6, 2003 (PubMed).

Validation Images
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