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MDC1 antibody (Mdc1) (AA 1883-2089)

Details for Product anti-MDC1 Antibody No. ABIN121711, Supplier: Login to see
Antigen
  • 6820401C03
  • AA413496
  • Nfbd1
  • mKIAA0170
  • NFBD1
Epitope
AA 1883-2089
35
18
13
9
5
4
3
2
1
1
1
1
1
Reactivity
Human
80
71
23
21
15
1
Host
Sheep
56
50
7
Clonality
Polyclonal
Conjugate
This MDC1 antibody is un-conjugated
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
86
62
22
16
11
11
10
5
1
1
Supplier
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Immunogen Recombinant MDC1 BRCT domains (aa 1883 - 2089)
Purification Serum
Alternative Name MDC1 (MDC1 Antibody Abstract)
Background Research suggest that MDC1 is involved in the early stages of response to DNA damage and may recruit other factor to sites of DNA damage.Synonyms: KIAA0170, MDC1, Mediator of DNA damage checkpoint protein 1, NFBD1
UniProt Q14676
Research Area Chromatin and Nuclear Signaling, DNA/RNA, Chemokines
Pathways
Application Notes ELISA: direct. Western Blot: 1:2000, this antibody detects 3 bands of approximately 250 kDa in HeLa and 293T cell lysates. Immunofluorescence: 1:500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Containing 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Stewart, Wang, Bignell et al.: "MDC1 is a mediator of the mammalian DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 961-6, 2003 (PubMed).

Lou, Minter-Dykhouse, Wu et al.: "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways." in: Nature, Vol. 421, Issue 6926, pp. 957-61, 2003 (PubMed).

Goldberg, Stucki, Falck et al.: "MDC1 is required for the intra-S-phase DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 952-6, 2003 (PubMed).