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Activation-Induced Cytidine Deaminase (AICDA) (C-Term) antibody

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Synonyms AID, AICDA, aid, arp2, cda2, higm2, xlaid, ARP2, CDA2, HIGM2, Aid, Arp2, 4921510D23Rik, AA409782, D6Ertd746e
(27), (24), (11), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(126), (55), (31), (6), (4), (4), (4), (3), (1), (1)
(83), (19), (18), (11)
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(115), (57), (19), (16), (12), (12), (8), (5), (5), (5), (3), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen A 14 amino acid peptide located near human AID carboxy-terminus
Specificity This antibody recognises an epitope within the C-terminal region (CT) of Activation-induced cytidine deaminase (AID), a 24 kDa homologue of the RNA-editing cytidine deaminase enzyme, APOBEC-1. Although the molecular mechanisms by which AID acts remain unclear, a growing number of studies reveal a requirement for AID during somatic hypermutation (SHM) and class switch recombination (CSR). These genetic modification events take place within highly specialised B cell germinal centres, during the final maturation stages of B cells, giving rise to high-affinity antibodies which use CSR to switch from IgM to IgG, IgA or IgE isotypes.
Purification Affinity chromatography
Alternative Name AICDA / AID (AICDA Antibody Abstract)
Background Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase
Gene ID 57379
UniProt Q9GZX7
Application Notes Western Blot: 2 μg/mL, this antibody detects a band of approximately 24 kDa in Ramos whole cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Yu, Roy, Bayramyan et al.: "Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1730-6, 2005 (PubMed).

Muramatsu, Kinoshita, Fagarasan et al.: "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme." in: Cell, Vol. 102, Issue 5, pp. 553-63, 2000 (PubMed).

Muramatsu, Sankaranand, Anant et al.: "Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells." in: The Journal of biological chemistry, Vol. 274, Issue 26, pp. 18470-6, 1999 (PubMed).

Catalog No. ABIN121895
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