Activation-Induced Cytidine Deaminase (AICDA) (C-Term) antibody

Details for Product No. ABIN121895
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Antigen
Synonyms AID, AICDA, aid, arp2, cda2, higm2, xlaid, ARP2, CDA2, HIGM2, Aid, Arp2, 4921510D23Rik, AA409782, D6Ertd746e
Epitope
C-Term
(18), (17), (12), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(85), (48), (21), (13), (5), (4), (2)
Host
Rabbit
(60), (23), (10), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(81), (48), (14), (12), (10), (9), (7), (6), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121895
412.50 $
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Immunogen A 14 amino acid peptide located near human AID carboxy-terminus
Specificity This antibody recognises an epitope within the C-terminal region (CT) of Activation-induced cytidine deaminase (AID), a 24 kDa homologue of the RNA-editing cytidine deaminase enzyme, APOBEC-1. Although the molecular mechanisms by which AID acts remain unclear, a growing number of studies reveal a requirement for AID during somatic hypermutation (SHM) and class switch recombination (CSR). These genetic modification events take place within highly specialised B cell germinal centres, during the final maturation stages of B cells, giving rise to high-affinity antibodies which use CSR to switch from IgM to IgG, IgA or IgE isotypes.
Purification Affinity chromatography
Alternative Name AICDA / AID
Background Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase
Gene ID 57379
UniProt Q9GZX7
Application Notes Western Blot: 2 μg/mL, this antibody detects a band of approximately 24 kDa in Ramos whole cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
General Muramatsu, Sankaranand, Anant et al.: "Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells." in: The Journal of biological chemistry, Vol. 274, Issue 26, pp. 18470-6, 1999 (PubMed).

Muramatsu, Kinoshita, Fagarasan et al.: "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme." in: Cell, Vol. 102, Issue 5, pp. 553-63, 2000 (PubMed).

Yu, Roy, Bayramyan et al.: "Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1730-6, 2005 (PubMed).

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