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Details for Product No. ABIN121896

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term) antibody

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Antigen
Synonyms A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, bK150C2.7, dJ494G10.1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN121896
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A 15 amino acid peptide located near human APOBEC3G amino-terminus
Isotype IgG
Purification Affinity Chromatography
Alternative Name APOBEC3G
Background APOBEC3G is a 46kDa multi-isoform endogenous deoxycytidine deaminase, which plays a major role in the defence of T lymphocytes against retroviral infection. The incorporation of APOBEC3G into HIV-1 virion DNA, results in the deamination of dC to dU in minus-strand viral DNA during reverse transcription, thereby generating G to A hypermutations in the newly- synthesised viral DNA. The effect of APOBEC3G is counteracted by the HIV protein Vif, thought to induce the degradation of APOBEC3G through a ubiquitin-dependant proteasomal pathway. Alternate Names: APOBEC-3G, ARP9, CEM15, MDS019, ARCD.
UniProt Q9HC16
Research Area Immunology, Chromatin Binding Proteins
Application Notes Western Blot: 5ug/ml, this antibody detects a band of approximately 46kDa in Human CaCO-2 cell lysates. Immunohistochemistry on paraffin sections: 1ug/ml. Recommended Positive Control: Spleen. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Chiu, Soros, Kreisberg et al.: "Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells." in: Nature, Vol. 435, Issue 7038, pp. 108-14, 2005 (PubMed).

Andrade, Goncalves: "[Traumatic spinal cord injury: neurologic and functional recovery]" in: Acta médica portuguesa, Vol. 20, Issue 5, pp. 401-6, 2008 (PubMed).

Alternatives for antigen "Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G)", type "Antibodies"
Hosts (50), (10), (8)
Reactivities (64), (3), (1)
Applications (63), (30), (21), (20), (2), (1)
Epitopes (21), (12), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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