Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term) antibody

Details for Product No. ABIN121896
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Antigen
Synonyms A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, bK150C2.7, dJ494G10.1
Epitope
N-Term
(27), (20), (10), (7), (7), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(90), (2), (1)
Host
Rabbit
(67), (16), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(86), (59), (35), (19), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN121896
401.50 $
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Immunogen A 15 amino acid peptide located near human APOBEC3G amino-terminus
Isotype IgG
Purification Affinity Chromatography
Alternative Name APOBEC3G
Background APOBEC3G is a 46kDa multi-isoform endogenous deoxycytidine deaminase, which plays a major role in the defence of T lymphocytes against retroviral infection. The incorporation of APOBEC3G into HIV-1 virion DNA, results in the deamination of dC to dU in minus-strand viral DNA during reverse transcription, thereby generating G to A hypermutations in the newly- synthesised viral DNA. The effect of APOBEC3G is counteracted by the HIV protein Vif, thought to induce the degradation of APOBEC3G through a ubiquitin-dependant proteasomal pathway. Alternate Names: APOBEC-3G, ARP9, CEM15, MDS019, ARCD.
UniProt Q9HC16
Research Area Immunology, Chromatin Binding Proteins
Application Notes Western Blot: 5ug/ml, this antibody detects a band of approximately 46kDa in Human CaCO-2 cell lysates. Immunohistochemistry on paraffin sections: 1ug/ml. Recommended Positive Control: Spleen. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Chiu, Soros, Kreisberg et al.: "Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells." in: Nature, Vol. 435, Issue 7038, pp. 108-14, 2005 (PubMed).

Andrade, Goncalves: "[Traumatic spinal cord injury: neurologic and functional recovery]" in: Acta médica portuguesa, Vol. 20, Issue 5, pp. 401-6, 2008 (PubMed).

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