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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term) antibody

Details for Product No. ABIN121896, Supplier: Log in to see
Antigen
  • A3G
  • ARCD
  • ARP-9
  • ARP9
  • CEM-15
  • CEM15
  • bK150C2.7
  • dJ494G10.1
Epitope
N-Term
53
35
15
14
13
11
8
8
4
3
3
2
2
2
2
1
1
1
Reactivity
Human
167
5
4
Host
Rabbit
128
21
18
Clonality
Polyclonal
Conjugate
Un-conjugated
11
11
11
10
10
10
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
138
98
64
19
11
7
5
1
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Immunogen A 15 amino acid peptide located near human APOBEC3G amino-terminus
Isotype IgG
Specificity This antibody recognises an epitope within the N-terminal region (NT) of APOBEC3G (apolipoprotein B mRNAediting, enzyme-catalytic, polypeptide-like 3G). This antibody also detects the APOBEC3F isoform (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3F).
Purification Affinity Chromatography
Alternative Name APOBEC3G (APOBEC3G Antibody Abstract)
Background APOBEC3G is a 46 kDa multi-isoform endogenous deoxycytidine deaminase, which plays a major role in the defence of T lymphocytes against retroviral infection. The incorporation of APOBEC3G into HIV-1 virion DNA, results in the deamination of dC to dU in minus-strand viral DNA during reverse transcription, thereby generating G to A hypermutations in the newly-synthesised viral DNA. The effect of APOBEC3G is counteracted by the HIV protein Vif, thought to induce the degradation of APOBEC3G through a ubiquitin-dependant proteasomal pathway.Synonyms: APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, ARP9, CEM15, DNA dC->dU-editing enzyme APOBEC-3G, MDS019
Gene ID 200316
UniProt Q9HC16
Research Area Immunology, Chromatin Binding Proteins
Pathways
Application Notes Western Blot: 5 μg/mL, this antibody detects a band of approximately 46 kDa in Human CaCO-2 cell lysates. Immunohistochemistry on paraffin sections: 1 μg/mL. Recommended Positive Control: Spleen.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Product cited in: Andrade, Goncalves: "[Traumatic spinal cord injury: neurologic and functional recovery]" in: Acta médica portuguesa, Vol. 20, Issue 5, pp. 401-6, 2008 (PubMed).

Background publications Chiu, Soros, Kreisberg et al.: "Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells." in: Nature, Vol. 435, Issue 7038, pp. 108-14, 2005 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).