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Details for Product No. ABIN121906

Toll-Like Receptor 5 (TLR5) antibody

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Synonyms SLEB1, TIL3, TLR-5, sleb1, til3, tlr-5
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN121906
Quantity 0.1 mg
423.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to a 16 amino acid sequence located near the centre of human TLR5
Purification Affinity chromatography
Alternative Name TLR5
Background TLR5 is expressed at high levels in the liver and detectable in small amounts in most other tissues. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR5 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and in turn tumour necrosis factor alpha and has been shown to recognise flagellin from both Gram-positive and Gram- negative bacteria.
UniProt O60602
Research Area Immunology, Innate Immunity, Signaling, Inflammation
Application Notes Western Blot: 1.0 - 2.0ug/ml, this antibody detects a band of approximately 97.6kDa in rat brain cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Hayashi, Smith, Ozinsky et al.: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5." in: Nature, Vol. 410, Issue 6832, pp. 1099-103, 2001 (PubMed).

Hawn, Verbon, Lettinga et al.: "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1563-72, 2003 (PubMed).

Alternatives for antigen "Toll-Like Receptor 5 (TLR5)", type "Antibodies"
Hosts (95), (28), (6)
Reactivities (121), (67), (34), (7), (1), (1), (1), (1), (1), (1)
Applications (100), (48), (34), (25), (22), (18), (10), (10), (2), (2), (2), (1), (1), (1)
Conjugates (9), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (9), (8), (6), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1)