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Toll-Like Receptor 5 (TLR5) antibody

Details for Product No. ABIN121906, Supplier: Login to see New
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Human, Mouse (Murine), Rat (Rattus)
(179), (87), (39), (2), (2)
(157), (41), (5)
(18), (11), (9), (6), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(157), (89), (67), (36), (22), (21), (11), (9), (8), (5), (3), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to a 16 amino acid sequence located near the centre of human TLR5
Specificity This antibody recognises Toll receptor 5 (TLR5), a 97.6 kDa member of the evolutionarily conserved toll-like receptor family (TLRs).
Purification Affinity chromatography
Alternative Name TLR5 (TLR5 Antibody Abstract)
Background TLR5 is expressed at high levels in the liver and detectable in small amounts in most other tissues. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR5 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and in turn tumour necrosis factor alpha and has been shown to recognise flagellin from both Gram-positive and Gram-negative bacteria.Synonyms: TIL3, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3
Gene ID 7100
UniProt O60602
Research Area Immunology, Innate Immunity, Signaling, Inflammation
Pathways TLR Signaling
Application Notes Western Blot: 1.0 - 2.0 μg/mL, this antibody detects a band of approximately 97.6 kDa in rat brain cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Hawn, Verbon, Lettinga et al.: "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1563-72, 2003 (PubMed).

Hayashi, Smith, Ozinsky et al.: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5." in: Nature, Vol. 410, Issue 6832, pp. 1099-103, 2001 (PubMed).

Catalog No. ABIN121906

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