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Toll-Like Receptor 5 (TLR5) antibody

Antigen

Toll-Like Receptor 5 (TLR5)
Synonyms TIL3, SLEB1, FLJ10052, MGC126430, MGC126431, TLR5, TLR-5, tlr-5
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
2 references available
Catalog no. ABIN121906
Quantity 0.1 mg  (1.0 mg/ml)  (Variants)
Price 407.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name TLR5
UniProt O60602
Immunogen Synthetic peptide corresponding to a 16 amino acid sequence located near the centre of human TLR5
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description TLR5 is expressed at high levels in the liver and detectable in small amounts in most other tissues. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR5 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and in turn tumour necrosis factor alpha and has been shown to recognise flagellin from both Gram-positive and Gram- negative bacteria.

Application Details
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Application Notes Western Blot: 1.0 - 2.0ug/ml, this antibody detects a band of approximately 97.6kDa in rat brain cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 1.0 mg/ml
Purification Affinity Purified
Buffer PBS containing 0.02% Sodium Azide
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Research Area Immunology, Innate Immunity, Signaling, Inflammation
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Hayashi, Smith, Ozinsky et al.: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5." in: Nature, Vol. 410, Issue 6832, pp. 1099-103, 2001 (PubMed).

Hawn, Verbon, Lettinga et al.: "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1563-72, 2003 (PubMed).