TSC1 antibody (Tuberous Sclerosis 1)

Details for Product anti-TSC1 Antibody No. ABIN121908, Supplier: Log in to see
Antigen
  • tsc1
  • wu:fc38b04
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
  • tuberous sclerosis 1
  • tuberous sclerosis 1b
  • TSC1
  • tsc1b
  • tsc1
  • Tsc1
Alternatives
anti-Human TSC1 antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
462
378
171
28
7
6
5
1
1
Host
Rabbit
742
57
19
2
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
5
5
5
5
5
3
3
3
3
3
3
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
532
518
165
66
39
34
27
21
16
8
4
2
1
Options
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Specificity This antibody recognises an epitope within the internal region of the 130 kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1).
Purification Affinity chromatography
Alternative Name TSC1 / Hamartin (TSC1 Antibody Abstract)
Background Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene. Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein
Gene ID 7248
UniProt Q92574
Pathways RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Inoki, Ouyang, Li, Guan: "Signaling by target of rapamycin proteins in cell growth control." in: Microbiology and molecular biology reviews : MMBR, Vol. 69, Issue 1, pp. 79-100, 2005 (PubMed).

Tee, Fingar, Manning, Kwiatkowski, Cantley, Blenis: "Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13571-6, 2002 (PubMed).