B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibody

Details for Product No. ABIN121913
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Antigen
Synonyms 6c6-ag, bap31, cdm, dxs1357e, BCAP31, Bap31, 6C6-AG, BAP31, CDM, DXS1357E, CALD1, caldesmon, si:bz30i22.4, si:rp71-30i22.4, zgc:56389
Epitope
C-Term
(21), (11), (6), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(115), (55), (51), (18), (15), (13), (4), (3), (1), (1), (1)
Host
Rabbit
(95), (8), (7), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(106), (58), (34), (24), (10), (10), (9), (9), (7), (6), (5), (4), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121913
357.50 $
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Specificity This antibody recognises an epitope within the C-terminal region (CT) of BAP31 (B cell receptor-associated protein 31).
Purification Affinity chromatography
Alternative Name BCAP31 / BAP31
Background BAP31 is a 28 kDa conserved type III integral membrane protein of the Endoplasmic Reticulum (ER), containing two caspase cleavage sites within its cytosolic domain. BAP31 appears to be a multi-functional ER-associated transport protein which was originally identified through its association with membrane IgD in B lymphocytes. Several proteins have since been shown to associate with BAP31, including the Beta2 integrin receptor CD11b/CD18, and nonmuscle gamma-actin and myosin B heavy chain. BAP31 has become a focus area for apoptosis studies due to its association with Bcl-2 and cleavage by initiator caspases including caspase 1 and 8. Cleavage of BAP31 generates a membrane-integrated p20 fragment which is itself a potent inducer of apoptosis when expressed ectopically.Synonyms: 6C6-AG tumor-associated antigen, B-cell receptor-associated protein 31, BCR-associated protein Bap31, DXS1357E, Protein CDM, p28 Bap31
Gene ID 10134
UniProt P51572
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline, 0.02 % Sodium Azide (NaN3)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Kim, Adachi, Nielsen et al.: "Two new proteins preferentially associated with membrane immunoglobulin D." in: The EMBO journal, Vol. 13, Issue 16, pp. 3793-800, 1994 (PubMed).

Ng, Nguyen, Kwan et al.: "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum." in: The Journal of cell biology, Vol. 139, Issue 2, pp. 327-38, 1997 (PubMed).

Ducret, Nguyen, Breckenridge et al.: "The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chain." in: European journal of biochemistry / FEBS, Vol. 270, Issue 2, pp. 342-9, 2003 (PubMed).

Zen, Utech, Liu et al.: "Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44924-30, 2004 (PubMed).

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