Interleukin 1 Receptor-Like 1 (IL1RL1) (N-Term) antibody

Details for Product No. ABIN121916
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Antigen
Epitope
N-Term
Reactivity
Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN121916
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Specificity This antibody recognises an epitope within the N-terminal region (NT) of ST2.
Purification Affinity Chromatography.
Alternative Name IL1RL1 / ST2
Background ST2 is a member of the Tollinterleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP (1), in line with its role as a crucial receptor in TH2-cell mediated responses (2).Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
Gene ID 17082
UniProt P14719
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Brint, Xu, Liu et al.: "ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance." in: Nature immunology, Vol. 5, Issue 4, pp. 373-9, 2004 (PubMed).

Coyle, Lloyd, Tian et al.: "Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses." in: The Journal of experimental medicine, Vol. 190, Issue 7, pp. 895-902, 1999 (PubMed).

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