Interleukin 1 Receptor-Like 1 (IL1RL1) (N-Term) antibody

Details for Product No. ABIN121916
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(10), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine)
(61), (20), (6)
(53), (18), (1), (1)
(6), (6), (2), (2)
Immunofluorescence (IF), Western Blotting (WB)
(53), (37), (14), (12), (7), (4), (4), (4), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Specificity This antibody recognises an epitope within the N-terminal region (NT) of ST2.
Purification Affinity Chromatography.
Alternative Name IL1RL1 / ST2 (IL1RL1 Antibody Abstract)
Background ST2 is a member of the Tollinterleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP (1), in line with its role as a crucial receptor in TH2-cell mediated responses (2).Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
Gene ID 17082
UniProt P14719
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Brint, Xu, Liu et al.: "ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance." in: Nature immunology, Vol. 5, Issue 4, pp. 373-9, 2004 (PubMed).

Coyle, Lloyd, Tian et al.: "Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses." in: The Journal of experimental medicine, Vol. 190, Issue 7, pp. 895-902, 1999 (PubMed).

Catalog No. ABIN121916
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