anti-AES antibody (Amino-terminal Enhancer of Split)

Details for Product anti-AES Antibody No. ABIN121926
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Synonyms grg, esp1, grg5, tle5, aes-1, aes-2, AES, AES-1, AES-2, ESP1, GRG, GRG5, TLE5, AL024115, Esp1, Grg, Grg-5, Grg5, Tle5, zgc:64216, xgrg-5
Human, Mouse (Murine), Rat (Rattus)
(95), (36), (22), (3), (3), (2), (1), (1)
(79), (12), (7)
This AES antibody is un-conjugated
(4), (4), (4), (4), (4), (4)
Immunofluorescence (IF), Western Blotting (WB)
(87), (41), (16), (7), (6), (5), (3), (3), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Purification Affinity chromatography
Alternative Name AES / ESP1 (AES Antibody Abstract)
Background The detachment of integrin from the extracellular matrix (ECM), results in loss of cell adhesion and cell death, termed anoikis. Studies show that this type of apoptosis is controlled by integrin-mediated signaling pathways and that the mitochondrial protein Bit1 (Bcl-2 inhibitor of transcription), released into the cytoplasm during apoptosis, forms a complex with AES, to induce cell death. The effects of the interaction between Bit1 and AES can be counteracted by the attachment of cells to fibronectin through integrin α5ß1.Synonyms: AES1, Amino-terminal enhancer of split, GRG protein, Gp130-associated protein GAM
UniProt Q08117
Pathways WNT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Jan, Matter, Pai et al.: "A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors." in: Cell, Vol. 116, Issue 5, pp. 751-62, 2004 (PubMed).

Tetsuka, Uranishi, Imai et al.: "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats." in: The Journal of biological chemistry, Vol. 275, Issue 6, pp. 4383-90, 2000 (PubMed).

Miyasaka, Choudhury, Hou et al.: "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein." in: European journal of biochemistry / FEBS, Vol. 216, Issue 1, pp. 343-52, 1993 (PubMed).

Catalog No. ABIN121926
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