Adiponectin (ADIPOQ ) (C-Term) antibody

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Antigen
Epitope
C-Term
56
43
25
13
13
11
11
10
7
6
6
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
487
172
132
30
16
4
4
4
3
1
1
1
Host
Rabbit
363
238
16
9
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
65
29
24
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
446
348
119
81
58
49
48
44
35
14
8
7
6
6
2
2
2
2
2
1
1
1
1
1
Options
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Immunogen A 15 amino acid peptide located near human Adiponectin carboxy-terminus
Specificity This antibody recognises an epitope within the C-terminal region (CT) of the 244 amino acid protein Adiponectin.
Purification Affinity Chromatography.
Alternative Name Adiponectin
Background Adiponectin (also known as Acrp30), is a major adipokine secreted into the bloodstream from adipose tissue to modulate metabolism, including glucose regulation and fatty acid catabolism. Unlike most other adipokines, Adiponectin is secreted exclusively by differentiating adipocytes at reduced levels during obesity. The serum level of Adiponectin is inversely correlated with BMI (body mass index) of an individual, and has an anti-inflammatory action, playing an important role in type II diabetes (insulin sensitivity) and atherosclerosis.Synonyms: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
Gene ID 9370
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes Immunohistochemistry on paraffin embedded sections (10 μg/mL, Positive control: rat brain). Western blotting (1.0-2.0 μg/mL, This antibody detects a band of approximately 26.4 kDa in human HL60 cell lysates).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline, pH 7.2 with 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C or at -20 °C for longer. Avoid repeated freezing and thawing. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: One year from despatch.
Expiry Date 12 months
Background publications Lihn, Pedersen, Richelsen: "Adiponectin: action, regulation and association to insulin sensitivity." in: Obesity reviews : an official journal of the International Association for the Study of Obesity, Vol. 6, Issue 1, pp. 13-21, 2005 (PubMed).

Trayhurn, Wood: "Signalling role of adipose tissue: adipokines and inflammation in obesity." in: Biochemical Society transactions, Vol. 33, Issue Pt 5, pp. 1078-81, 2005 (PubMed).

Wong, Wang, Hug, Tsao, Lodish: "A family of Acrp30/adiponectin structural and functional paralogs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10302-7, 2004 (PubMed).