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CCR7 antibody

CCR7 Reactivity: Human IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN122024
  • Target See all CCR7 Antibodies
    CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))
    Reactivity
    • 87
    • 48
    • 37
    • 16
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 69
    • 18
    • 7
    • 4
    Rabbit
    Clonality
    • 62
    • 35
    • 1
    Polyclonal
    Conjugate
    • 47
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCR7 antibody is un-conjugated
    Application
    • 52
    • 48
    • 21
    • 19
    • 17
    • 16
    • 15
    • 14
    • 14
    • 9
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    Reacts with CCR7 (family: GPCR, subfamily: Chemokine)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Peptide Immunogen Affinity Chromatography.
    Immunogen
    Synthetic peptide - KLH conjugated
    Top Product
    Discover our top product CCR7 Primary Antibody
  • Application Notes
    Immunohistochemistry with formalin fixed paraffin embedded tissues: 14 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.7 containing 0.09 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))
    Alternative Name
    CD197 / CCR7 (CCR7 Products)
    Synonyms
    zgc:165629 antibody, ccr7-a antibody, CD197 antibody, Cdw197 antibody, Cmkbr7 antibody, EBI1 antibody, Ebi1h antibody, BLR2 antibody, CDw197 antibody, CMKBR7 antibody, chemokine (C-C motif) receptor 7 antibody, C-C motif chemokine receptor 7 antibody, C-C motif chemokine receptor 7 L homeolog antibody, ccr7 antibody, CCR7 antibody, ccr7.L antibody, Ccr7 antibody
    Background
    CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. This receptor is particularly expressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.Synonyms: BLR2, C-C CKR-7, C-C chemokine receptor type 7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EBV-induced G-protein coupled receptor 1, EVI1, MIP-3 beta receptor
    Gene ID
    1236
    UniProt
    P32248
    Pathways
    Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process
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