CysLTR1 antibody (C-Term)

Catalog No. ABIN122044

Product Details anti-CysLTR1 Antibody

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CysLTR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with Cysteinyl Leukotriene Receptor 1 (family: GPCR, subfamily: Chemoattractant).

Cross-Reactivity (Details): Species reactivity (expected):MouseSpecies reactivity (tested):Human

Characteristics: Synonyms: Cysteinyl leukotriene receptor 1, CysLTR1, LTD4 receptor, HG55, HMTMF81, Cysteinylleukotriene D4 receptor, G-protein coupled receptor HG55

Purification: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugatedEpitope: C-terminal domain of humanGenename: CYSLTR1Remarks: The immunizing peptide shows 90 % identity (100 % similarity) with mouse and85 % identity (100 % similarity) with rat.

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 9-22 μg/mLAntigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch

Expiry Date: 12 months

Target Details for CysLTR1

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Alternative Name: CYSLTR1 (CYSLTR1 Products)

Synonyms: zgc:112062 antibody, CYSLTR1 antibody, CYSLT1 antibody, CYSLT1R antibody, CYSLTR antibody, HMTMF81 antibody, BB147369 antibody, CysLT1R antibody, Cyslt1 antibody, cysLT1R antibody, cysteinyl leukotriene receptor 1 antibody, cysltr1 antibody, CYSLTR1 antibody, Cysltr1 antibody, LOC100338776 antibody

Background: Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma. Ligand: The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4) activate at least two receptors, CysLT1 and CysLT2, to mediate human bronchial asthma. LTC(4), LTD(4), and LTE(4) are a class of peptide-conjugated lipids formed from arachidonic acid and that are released during activation of mast cells.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor

Gene ID: 10800

UniProt: Q9Y271