Glutamate Receptor, Metabotropic 2 (GRM2) antibody

Antigen: Glutamate Receptor, Metabotropic 2 (GRM2)

Synonyms: GLUR2, mGlu2, GPRC1B, MGLUR2, GRM2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN122312

Additional Information

Alternative name: MGluR2 / GRM2

Swiss-Prot: Q14416

Immunogen: Synthetic peptide - KLH conjugated

Description: The Metabotropic Glutamate Receptor GRM2 binds L-glutamate and has been linked to the inhibition of the cyclic AMP signaling cascade. GRM2 is involved in mediating the suppression of neurotransmission and in synaptogenesis and synaptic stabilization. Glutamatergic neurotransmission plays a role in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. GRM2 has been reported in various regions of the human and animal brain, as well as in rat eye and spinal cord. ESTs have been isolated from brain and testis libraries. Caution: GLUR2 refers to Ionotropic Glutamate Receptor 2, not to Metabotropic Glutamate Receptor 2 (mGLUR2). Alternate Names: MGLU2, MGLUR2, GLUR2, GPRC1B, glutamate receptor, metabotropic 2, grm2, metabotropic glutamate receptor type ii, mGlu2 receptor, mglur2.

Specificity: Reacts with Metabotropic Glutamate Receptor 2 (family: GPCR, subfamily: Metabotropic glutamate).The immunizing peptide shows 100 % identity (100 % similarity) with mouse and 100 % identity (100 % similarity) with rat

Application Details

Application Notes: Western Blot. Immunocytochemistry. Immunohistochemistry with formalin fixed paraffin embedded tissues: 4-8 ug/ml Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Concentration: 1.0 mg/ml

Buffer: PBS, pH 7.7, containing 0.01% sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C forlonger. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only

Images

Cells expressing target protein - immunostained with target antibody