Glutamate Receptor, Metabotropic 7 (GRM7) antibody

Antigen: Glutamate Receptor, Metabotropic 7 (GRM7)

Synonyms: GLUR7, MGLU7, GPRC1G, MGLUR7, FLJ40498, Gpr1g, Gprc1g, mGluR7, BB176677, MGC90857, C030018L03, 6330570A01Rik, E130018M02Rik, GRM7, MGC151963, DKFZp459P0826

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN122319

Additional Information

Alternative name: MGluR7 / GRM7

Swiss-Prot: Q14831

Immunogen: Synthetic peptide - KLH conjugated

Description: Metabotropic Glutamate Receptor GRM7 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. GRM7 is highly concentrated at presynaptic terminals and is thought to play an important role in the modulation of glutamatergic synaptic transmission by effecting presynaptic inhibition of glutamate release. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors, which are linked to inhibition of the cyclic AMP signaling cascade. Five mRNA variants of GRM7 have been described, most of the variants are expressed in brain and retina, although there are non-neuronal variants that may have different functional properties. GRM7 has been reported to be expressed in active zones of presynaptic axon terminals in various regions of the brain, eye, and spinal cord. Caution: GLUR7 refers to Ionotropic Glutamate Receptor 7, not to Metabotropic Glutamate Receptor 7 (mGLUR7). Alternate Names: MGLU7, MGLUR7, GLUR7, GPRC1G, glutamate receptor, metabotropic 7, grm7, metabotropic glutamate receptor type 7, MGLU7 RECEPTOR, mglur7.

Specificity: Reacts with Metabotropic Glutamate Receptor 7 (.The immunizing peptide shows 100 % identity (100 % similarity) with mouse

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 10 ug/ml Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Concentration: 1 mg/ml

Buffer: PBS, pH 7.7, containing 0.01% sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only