PTGDR antibody (Extracellular Domain)

Catalog No. ABIN122373

Product Details anti-PTGDR Antibody

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Binding Specificity: Extracellular Domain

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGDR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with Prostaglandin D2 Receptor (family: GPCR, subfamily: Prostanoid).

Purification: Peptide Immunogen Affinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues: 4-7 μg/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min, Remove from heat and let stand at room temperature in buffer for 20 min, Rinse in 1x TBS with Tween (TBST) for 1 min at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline, pH 7.7 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to 70 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

References for anti-PTGDR antibody (ABIN122373)

Dash, Ghatak, Topi, Satapathy, Ek, Hellman, Olsson, Mehdawi, Sjölander: "High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model." in: British journal of cancer, Vol. 126, Issue 4, pp. 586-597, (2022) (PubMed).

Target Details for PTGDR

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Alternative Name: PTGDR (PTGDR Products)

Synonyms: AS1 antibody, ASRT1 antibody, DP antibody, DP1 antibody, PTGDR1 antibody, Ptgdr antibody, Ptgdr2 antibody, PTGDR antibody, PGD antibody, prostaglandin D2 receptor antibody, prostaglandin D receptor antibody, PTGDR antibody, Ptgdrl antibody, Ptgdr antibody

Background: The prostaglandin D2 receptor is a Prostanoid Receptor that binds prostaglandin D2. Studies suggest that this receptor may be involved in vision, mucous secretion, myometrial relaxation, and asthmatic response. Prostaglandin D2 receptor has been reported to be expressed in human small intestine, colon (goblet cells), eye, and eosinophils. ESTs have been isolated from human brain libraries.Synonyms: ASRT1, PGD receptor, PGD2 receptor, Prostaglandin D2 receptor, Prostanoid DP receptor

Gene ID: 5729

UniProt: Q13258

Pathways: Thromboxane A2 Receptor Signaling