LHCGR antibody (C-Term)

Catalog No. ABIN122503

Product Details anti-LHCGR Antibody

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Peptide Immunogen Affinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated. Epitope: C-terminal domain of human. Remarks: The immunizing peptide shows 78% identity (84% similarity) with Mouse and 94% identity (100% similarity) with Rat.

Application Details

Application Notes: Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

References for anti-LHCGR antibody (ABIN122503)

Sand, Bergvall, Ekblad, DAmato, Ohlsson: "Expression and distribution of GnRH, LH, and FSH and their receptors in gastrointestinal tract of man and rat." in: Regulatory peptides, Vol. 187, pp. 24-8, (2013) (PubMed).

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: Luteinizing Hormone Receptor (LHCGR) (LHCGR Products)

Synonyms: HHG antibody, LCGR antibody, LGR2 antibody, LH/CG-R antibody, LH/CGR antibody, LHR antibody, LHRHR antibody, LSH-R antibody, ULG5 antibody, Gpcr19-rs1 antibody, LH-R antibody, Lhr antibody, LSHR antibody, lhr antibody, GTHR-II antibody, zfGTHR-II antibody, LHCGR antibody, LOC100222883 antibody, lh-r antibody, LOC100305044 antibody, luteinizing hormone/choriogonadotropin receptor antibody, luteinizing hormone/choriogonadotropin receptor L homeolog antibody, luteinizing hormone receptor antibody, LHCGR antibody, Lhcgr antibody, lhcgr antibody, lhcgr.L antibody, lhr antibody, LOC100305044 antibody

Background: LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed. LHCGR has been reported in brain, cervix, epididymis, ovary, placenta, prostate, testis, umbilical cord, and uterus. ESTs have been isolated from fetal lung/testis/B-cell and testis libraries.Synonyms: LCGR, LGR2, LH/CG-R, LHCGR, LHR, LHRHR, LSH-R, Luteinizing hormone receptor, Lutropin-choriogonadotropic hormone receptor

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling