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Metabotropic Glutamate Receptor 4 antibody (C-Term)

GRM4 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN122590
  • Target See all Metabotropic Glutamate Receptor 4 (GRM4) Antibodies
    Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))
    Binding Specificity
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 18
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 17
    • 1
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Metabotropic Glutamate Receptor 4 antibody is un-conjugated
    Application
    • 9
    • 9
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody reacts with mGluR4 / GRM4 at C-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat (see 'Immunogen Remarks')Species reactivity (tested):Human
    Purification
    Peptide immunogen affinity column
    Immunogen
    Synthetic peptide - KLH conjugated
    Top Product
    Discover our top product GRM4 Primary Antibody
  • Application Notes
    Western Blot. Immunohistochemistry on paraffin embedded sections. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % Sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))
    Alternative Name
    mGluR4 / GRM4 (GRM4 Products)
    Synonyms
    GPRC1D antibody, MGLUR4 antibody, mGlu4 antibody, Gprc1d antibody, mGluR4 antibody, glutamate metabotropic receptor 4 antibody, glutamate receptor, metabotropic 4 antibody, GRM4 antibody, Grm4 antibody
    Background
    The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa, mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).Synonyms: GPRC1D, MGLUR4, Metabotropic glutamate receptor 4
    Gene ID
    2914
    UniProt
    Q14833
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