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APH1A antibody (Anterior Pharynx Defective 1 Homolog A (C. Elegans)) (C-Term)

Details for Product anti-APH1A Antibody No. ABIN123019, Supplier: Login to see New
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C-Term, AA 245-265
(43), (24), (15), (13), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(95), (49), (30), (3), (3), (2), (1)
(82), (22)
This APH1A antibody is un-conjugated
(6), (6), (5), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(91), (62), (22), (20), (11), (3), (2)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen The immunogen is a synthetic peptide, KLH conjugated, corresponding to residues 245-265 of the C-Terminal domain of the long isoform of APH-1a. AA Sequence:C(245) R R Q E D S R V M V Y S A L R I P P E D (265)
Specificity The antibody detects APH-1.
Purification Affinity chromatography
Alternative Name APH1A (APH1A Antibody Abstract)
Background Familial Alzheimer's disease is often characterized by an early ( < 60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. APH-1 has been found to be a member of the presenilin (PS) complex, and likely contributes to the gamma-secretase activity involved with the onset of Alzheimer's. Recent evidence has shown that APH-1 also plays a role in the maturation of nicastrin/presenilin complexes.Synonyms: APH-1A, Aph-1 alpha, CGI-78, Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor
Gene ID 51107
UniProt Q96BI3
Pathways Notch Signaling, Neurotrophin Signaling Pathway
Application Notes Western Blot (1/1000): detects a approx. 18 kDa protein representing APH-1 in mouse brain and kidney extracts. Immunofluorescence (1/100). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This polyclonal antibody has been referred to as O2C2.
Restrictions For Research Use only
Concentration 0.69 mg/mL
Buffer PBS containing 1 mg/mL BSA and 0.005 % sodium azide and glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-APH1A antibody (Anterior Pharynx Defective 1 Homolog A (C. Elegans)) (C-Term) (ABIN123019) Figure 1 shows a Western blot of APH-1 in mouse brain and kidney extracts using ABIN1...
Immunofluorescence (IF) image for anti-APH1A antibody (Anterior Pharynx Defective 1 Homolog A (C. Elegans)) (C-Term) (ABIN123019) Figure 2 shows immunofluorescence staining of APH-1 in human KNS-42 glioma cells usin...
Background publications Gu, Chen, Sanjo et al.: "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7374-80, 2003 (PubMed).

Catalog No. ABIN123019

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