Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (C-Term), (AA 245-265) antibody

Details for Product No. ABIN123019
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Antigen
Synonyms Aph-1, Aph1, 6530402N02Rik, APH-1a, APH-1, APH-1A, CGI-78, RGD1311546
Epitope
C-Term, AA 245-265
(24), (7), (7), (5), (4), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(70), (39), (27), (13), (13), (13)
Host
Rabbit
(64), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(59), (41), (15), (14), (10), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN123019
478.50 $
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Immunogen The immunogen is a synthetic peptide, KLH conjugated, corresponding to residues 245-265 of the C-Terminal domain of the long isoform of APH-1a. AA Sequence:C(245) R R Q E D S R V M V Y S A L R I P P E D (265)
Purification Affinity chromatography
Alternative Name APH1A
Background Familial Alzheimer's disease is often characterized by an early ( < 60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. APH-1 has been found to be a member of the presenilin (PS) complex, and likely contributes to the gamma-secretase activity involved with the onset of Alzheimer's. Recent evidence has shown that APH-1 also plays a role in the maturation of nicastrin/presenilin complexes.
UniProt Q96BI3
Application Notes Western Blot (1/1000): detects a ~18 kDa protein representing APH-1 in mouse brain and kidney extracts. Immunofluorescence (1/100). Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This polyclonal antibody has been referred to as O2C2.
Restrictions For Research Use only
Format Liquid
Concentration 0.69 mg/mL
Buffer PBS containing 1 mg/ml BSA and 0.005% sodium azide and glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (C-Term), (AA 245-265) antibody Figure 2 shows immunofluorescence staining of APH-1 in human KNS-42 glioma cells using ABIN123019.
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (C-Term), (AA 245-265) antibody (2) Figure 1 shows a Western blot of APH-1 in mouse brain and kidney extracts using ABIN123019.
General Gu, Chen, Sanjo et al.: "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7374-80, 2003 (PubMed).

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