Synucelin, beta- (SNCB) antibody

Details for Product No. ABIN123078
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Antigen
Reactivity
Human
(19), (4), (1)
Host
Rabbit
(12), (4), (3), (1)
Clonality
Polyclonal
Application
Western Blotting (WB), ELISA
(11), (8), (6), (4), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123078
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Immunogen Recombinant human b -Synuclein purified from E. coli
Specificity This antibody is specific for b -Synuclein and does not cross react with a - and g -Synuclein.
Purification Purified
Alternative Name Beta-Synuclein / SCNB
Background Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: a -synuclein, b -Synuclein, and g -Synuclein. All Synucleins have in common a highly conserved a -helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Although they are homologous, each Synuclein is encoded by a different gene on chromosomes 4q21.3-q22. b -Synuclein, also known as PNP 14, is expressed in the brain, specifically in synapses around neurons, but not in glial cells. The protein, which has also been designated as a phosphoneuroprotein, has been found to be phosphorylated in vitro and in vivo. Alternate Names: Synuclein-beta.
UniProt Q16143
Research Area Neurology
Application Notes ELISA. Western blot (1:2,000 - 1:4,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).

Nakajo, Tsukada, Omata et al.: "A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation." in: European journal of biochemistry / FEBS, Vol. 217, Issue 3, pp. 1057-63, 1993 (PubMed).

Galvin, Uryu, Lee et al.: "Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13450-5, 1999 (PubMed).

Hashimoto, Bar-On, Ho et al.: "Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23622-9, 2004 (PubMed).

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