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5HT1B Receptor antibody (Serotonin Receptor 1B) (AA 8-26)

Details for Product anti-HTR1B Antibody No. ABIN123273, Supplier: Login to see New
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AA 8-26, AA 263-278
(13), (12), (10), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(49), (19), (17), (3), (3), (3), (1), (1), (1)
(37), (15), (2)
This 5HT1B Receptor antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (1)
Western Blotting (WB)
(42), (33), (9), (7), (5), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Mixture of synthetic peptides corresponding to amino acids 8-26 and 263-278 of rat 5-HT1BR (6).
Purification Protein G Chromatography
Background Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1). Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase (2). Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum (3,4). The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei (5).
UniProt P28564
Pathways JAK-STAT Signaling
Application Notes Western blotting (use at 1 ug/ml). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.2 with 0.02% Sodium Azide as preservative..
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-5HT1B Receptor antibody (Serotonin Receptor 1B) (AA 8-26) (ABIN123273) Western blot analysis of 5-HT1BR in human brain lysate with anti-5-HT1BR pcAb ABIN123...
General Bruinvels, Landwehrmeyer, Gustafson et al.: "Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain." in: Neuropharmacology, Vol. 33, Issue 3-4, pp. 367-86, 1994 (PubMed).

Pazos, Cortes, Palacios: "Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors." in: Brain research, Vol. 346, Issue 2, pp. 231-49, 1985 (PubMed).

Pazos, Palacios: "Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors." in: Brain research, Vol. 346, Issue 2, pp. 205-30, 1985 (PubMed).

Catalog No. ABIN123273

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