Serotonin Receptor 3A (HTR3A) (AA 21-36), (AA 421-436) antibody

Details for Product No. ABIN123275
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AA 21-36, AA 421-436
(18), (15), (8), (6), (5), (2), (2), (2), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(70), (16), (6), (2)
(57), (18), (1)
(3), (3), (3), (3), (3), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(74), (42), (11), (11), (9), (8), (4), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN123275
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Immunogen Mixture of synthetic peptides corresponding to amino acids 21-36 and 421-436 of rat 5-HT3 receptor
Purification Protein G Chromatography
Background Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1). The 5-HT3 receptors are distinguished from other 5-HT receptors by their structure and function. 5-HT3 receptors span the membrane only four times and are ligand-gated, cation-selective ion channels that mediate neuronal excitation and exocytotic release of neurotransmitters within the peripheral and central nervous systems (2,3). Functional studies done on isolated tissues have revealed heterogeneity of this receptor. The human 5-HT3R-As cDNA contains an open reading frame of 1434 base pairs predicting a 23-residue signal peptide and a mature receptor subunit of 455 amino acids (4). The human subunit exhibits 85% and 84% amino acid sequence identity to the mouse (5) and rat (6) receptors, respectively.
UniProt P46098
Application Notes Western blot (1 ug/ml). Recommended positive control: human brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Serotonin Receptor 3A (HTR3A) (AA 21-36), (AA 421-436) antibody Western blot analysis of 5-HT3R in human brain tissue lysate with anti-5-HT3R pcAb ABIN123275. A protein band of approximate molecular weight of 47-50 kDa
General Morales, Battenberg, de Lecea et al.: "Cellular and subcellular immunolocalization of the type 3 serotonin receptor in the rat central nervous system." in: Brain research. Molecular brain research, Vol. 36, Issue 2, pp. 251-60, 1996 (PubMed).

Derkach, Surprenant, North: "5-HT3 receptors are membrane ion channels." in: Nature, Vol. 339, Issue 6227, pp. 706-9, 1989 (PubMed).

Maricq, Peterson, Brake et al.: "Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel." in: Science (New York, N.Y.), Vol. 254, Issue 5030, pp. 432-7, 1991 (PubMed).

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