V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) antibody

Details for Product No. ABIN123279
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Antigen
Reactivity
Human
(253), (112), (98), (24), (23), (21), (21), (12), (4), (2), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(194), (52), (10), (2), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (8), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(223), (125), (95), (41), (39), (33), (24), (15), (13), (10), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN123279
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Immunogen Human Akt2. AA Sequence:319-331
Purification Protein G chromatography
Alternative Name AKT2 / PKB beta
Background Akt, protein kinase B (PKB), is a serine/threonine kinase, which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
UniProt P31751
Research Area Signaling
Application Notes Western blotting (1-2 ug/ml). Use HeLa as positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C for one month or at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) antibody Western blot analysis of Akt2/3 using ABIN123279 at 1 µg/ml against 15 µg of HeLa lysate.
General Cheng, Godwin, Bellacosa et al.: "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 19, pp. 9267-71, 1992 (PubMed).

Cheng, Ruggeri, Klein et al.: "Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 8, pp. 3636-41, 1996 (PubMed).

Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

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