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Runt-Related Transcription Factor 1 (RUNX1) antibody

Antigen

Runt-Related Transcription Factor 1 (RUNX1)
Synonyms AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1, CDR, ETO, MTG8, MTG8b, AML1T1, ZMYND2, CBFA2T1, MGC2796, RUNX1, runx1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
1 reference available
Catalog no. ABIN123281
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 308.00 $   Plus shipping costs $45.00
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anti-Runt-Related Transcription Factor 1 (RUNX1) antibody

Additional Information
Application Details Publications Images Alternatives Variants back to top

Alternative name RUNX1
UniProt Q01196
Immunogen Synthetic peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO (amino acids 231 to 245 of human origin) AA Sequence:AFNPQPQSQMQDTRQ
Cross-Reactivity Human, Mouse (Murine)
Description AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. The AML1 gene on chromosome 21 is disrupted in the (8,21)(q22,q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. AML-1 translocation is frequently observed in acute myeloid leukemia. It is a key transactivator of tissue-specific genes of the hematopoietic and bone lineages. Alternate Names: CBFA2 / Runx1.

Application Details
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Application Notes Western blot: 2-5 ug/ml. Recommended Positive Control: Ramos, Raw. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
Purification Purified
Buffer PBS containing 0.2 % gelatin, 0.05 % sodium azide
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C. Avoid repeated freezing and thawing. Centrifuge vial before opening. Shelf Life: One year from despatch.
Restrictions For Research Use only

Publications
Application Details Images Alternatives Variants back to top

Davis, McGhee, Meyers: "The ETO (MTG8) gene family." in: Gene, Vol. 303, pp. 1-10, 2003 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Runt-Related Transcription Factor 1 (RUNX1)", type "Antibodies"
Hosts Rabbit (93), Mouse (21), Sheep (3), Goat (1)
Reactivities Human (110), Mouse (Murine) (56), Rat (Rattus) (56), Cow (Bovine) (47), Dog (Canine) (47), Pig (Porcine) (23), Guinea Pig (18), Horse (Equine) (18), Rabbit (18), Xenopus laevis (5), Chicken (3), Zebrafish (3)
Applications Western Blotting (WB) (73), Immunofluorescence (IF) (53), ELISA (49), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), Immunohistochemistry (IHC) (17), Immunocytochemistry (ICC) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Flow Cytometry (FACS) (4), Immunoprecipitation (IP) (3), Dot Blot (Dot) (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2)
Conjugates FITC (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE (2), PE,Cy5.5 (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pSer249 (19), Internal Region (12), pSer303 (5), C-Term (4), N-Term (2), pSer276 (2), pSer435 (2), AA 231-245 (1), AA 240-252 (1), Middle Region (1), Ser276 (1), pTyr1283,pTyr1282,pTyr1278 (1)