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Lethal Factor (LEF) (AA 47-65) antibody

Details for Product No. ABIN123282
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Antigen
Epitope
AA 47-65
(3), (1), (1)
Reactivity
Bacillus anthracis
(24)
Host
Rabbit
(18), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(15), (10), (7), (4), (3)
Pubmed 1 reference available
Quantity 0.2 mL
Shipping to United States (Change)
Availability Discontinued
Catalog No. ABIN123282
456.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptides corresponding to amino acids 47-65 of the Anthrax LF protein (~90 kD)
Purification Serum
Alternative Name Lethal Factor (LF)
Background Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxicity to occur. It begins with the binding of PA to its cell-surface receptor, ATR (Anthrax Toxin Receptor), at which point PA is cleaved and the resulting 63 kD carboxyl-terminal fragment binds to LF and EF. LF is a protease that is known to cleave members of the mitogen-activated protein kinase kinase (MAPKK) family (2).
UniProt P15917
Application Notes Western blot: 1/1000. Recommended positive control: recombinant protein. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.2 % gelatin and 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Lethal Factor (LEF) (AA 47-65) antibody Western blot analysis of Anthrax LF in recombinant protein using ABIN123282 (lane B) at 1:1000 dilution. Lane A shows the pre-bleed.
General Collier, Young: "Anthrax toxin." in: Annual review of cell and developmental biology, Vol. 19, pp. 45-70, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN123282
456.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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