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Details for Product No. ABIN123283

Anthrax Protective Antigen (PA) (AA 238-254) antibody

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Antigen
Epitope
»Alternatives AA 238-254
Reactivity
»Alternatives Bacillus anthracis
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN123283
Quantity 0.2 mL
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptides corresponding to amino acids 238-254 of the Anthrax PA protein (~83 kD)
Purification Serum
Alternative Name Bacillus anthracis protective antigen
Background Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxic entry into cells. PA is secreted from Bacillus anthracis as an 83 kDa (PA83) protein which is cleaved by furin protease, releasing a 20 kDa fragment. The 63 kDa portion (PA63) of the cleavage product forms a heptamer, which binds the toxins LF and EF. This complex enters via receptor-mediated endocytosis where LF and EF exert their toxic effects.
UniProt P13423
Research Area Bacteria, Gram positive bacteria, Toxins, Virology
Application Notes Western blot: 1:1000. Recommended Positive Control: PA recombinant protein. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.2 % gelatin and 0.05 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Collier, Young: "Anthrax toxin." in: Annual review of cell and developmental biology, Vol. 19, pp. 45-70, 2003 (PubMed).

Alternatives for antigen "Anthrax Protective Antigen (PA)", type "Antibodies"
Hosts (57), (27), (5)
Reactivities (22), (17), (4), (4), (3)
Applications (76), (34), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Conjugates (2), (1)
Epitopes (8), (6), (1), (1), (1), (1)
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