Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN123285

Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
APAF-1, CED4, 6230400I06Rik, Apaf-1, Apaf1l, fog, mKIAA0413, apaf-1, zgc:136543, APAF1, ARK, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dAp ... show more
Epitope
»Alternatives AA 12-28
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN123285
Quantity 0.1 mg
Price
654.50 $   Plus shipping costs $45.00
Shipping to
Availability Discontinued
Immunogen Peptide corresponding to amino acids 12 to 28 of human Apaf1 (1).
Purification Protein G chromatography
Alternative Name APAF1
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 is ubiquitously expressed in human tissues (1).
UniProt O14727
Research Area Cancer, Apoptosis/Necrosis
Application Notes Western blot: 1/1000 - 1/2000. Recommended Positive Control: HeLa. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Zou, Henzel, Liu et al.: "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3." in: Cell, Vol. 90, Issue 3, pp. 405-13, 1997 (PubMed).

Cecconi, Alvarez-Bolado, Meyer et al.: "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development." in: Cell, Vol. 94, Issue 6, pp. 727-37, 1998 (PubMed).

Hsiao, Wang, Li et al.: "The Winter procedure as management for prolonged low-flow priapism: a case report." in: The Kaohsiung journal of medical sciences, Vol. 23, Issue 10, pp. 531-5, 2007 (PubMed).

Alternatives for antigen "Apoptotic Peptidase Activating Factor 1 (APAF1)", type "Antibodies"
Hosts (133), (29), (6), (3)
Reactivities (162), (89), (79), (24), (15), (12), (1), (1), (1), (1), (1), (1)
Applications (122), (48), (46), (45), (24), (20), (11), (9), (8), (4), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (49), (35), (11), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Beacon