Ankyrin Repeat and SOCS Box-Containing 11 (ASB11) antibody

Antigen: Ankyrin Repeat and SOCS Box-Containing 11 (ASB11)

Synonyms: 1110067L12Rik, 1600009D24Rik, MGC119168, MGC119169, DKFZp779E2460, RGD1566298, ASB11, MGC128419, asb-a, MGC136370, MGC158532, MGC191227, zgc:136370, zgc:158532, DKFZp468G0324

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN123291

Additional Information

Alternative name: ASB11

UniProt: Q8WXH4

Immunogen: Synthetic peptides corresponding to amino acids 40-51 and 250-265 of human Asb-11

Cross-Reactivity: Human

Description: The ankyrin repeat and SOCS box-containing (Asb) protein family is comprised of members which each contain 'SOCS boxes' but differ from other families of protein in the motifs they contain upstream of the SOCS box (1). SOCS boxes are carboxy-terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases.

Application Details

Application Notes: Western blotting (1:500-1:1000). Recommended Positive Control: human liver. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Purified

Buffer: PBS containing 0.02 % sodium azide and 0.1 mg/ml BSA

Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.

Research Area: Chromatin and Nuclear Signaling, Cell Cycle, Transcription Factors

Restrictions: For Research Use only

Images

Western blot analysis of Asb-11 in 15 ugs of human liver cell lysate using ABIN123291 at 1:1000dilution.

Publications

Krebs, Hilton: "SOCS proteins: negative regulators of cytokine signaling." in: Stem cells (Dayton, Ohio), Vol. 19, Issue 5, pp. 378-87, 2001 (PubMed).

Wang, Campbell: "Cytokine signaling in the brain: putting a SOCS in it?" in: Journal of neuroscience research, Vol. 67, Issue 4, pp. 423-7, 2002 (PubMed).