anti-ATF2 antibody (Activating Transcription Factor 2)

Details for Product anti-ATF2 Antibody No. ABIN123294
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Antigen
Reactivity
Human
(596), (331), (318), (7), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(545), (28), (19), (7)
Clonality
Polyclonal
Conjugate
This ATF2 antibody is un-conjugated
(16), (16), (16), (10), (10), (10), (10), (10), (10), (10), (10), (6), (6), (6)
Application
Western Blotting (WB)
(412), (272), (173), (100), (97), (97), (95), (20), (10), (9), (9), (5), (3), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen Swiss-Prot ID: P15336
Purification Protein G Chromatography
Alternative Name ATF2 (ATF2 Antibody Abstract)
Background ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
UniProt P15336
Research Area Immunology, Innate Immunity, Transcription Factors
Pathways MAPK Pathway
Application Notes Western blot: 2 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Activating Transcription Factor 2 (ATF2) antibody Staining of 293 cell lysate. using ABIN123294
anti-Activating Transcription Factor 2 (ATF2) antibody (2) Detection of ATF2 in 293 cell lysate using ABIN123294 at 2 µg/ml.
General Benbrook, Jones: "Heterodimer formation between CREB and JUN proteins." in: Oncogene, Vol. 5, Issue 3, pp. 295-302, 1990 (PubMed).

Hai, Curran: "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 9, pp. 3720-4, 1991 (PubMed).

Validation Images
Catalog No. ABIN123294
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