Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (C-Term), (AA 254-269) antibody

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Antigen
Synonyms DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, RGD1561519, BLyS, D8Ertd387e, zTNF4, TNFSF13B
Epitope
C-Term, AA 254-269
(19), (6), (6), (5), (4), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(156), (44), (42), (12), (12)
Host
Rabbit
(79), (57), (27), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (11), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(114), (81), (44), (29), (22), (16), (10), (9), (7), (7), (4), (4), (4), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN123300
Quantity 0.1 mg
Price
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Immunogen C-terminal peptide corresponding to amino acids 254-269 of human BAFF
Purification Protein G chromatography
Alternative Name CD257 / BAFF
Background Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (6), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (5), BAFF (for B cell activating factor belonging to the TNF family) (4) and Blys (B lymphocyte stimulator) (3). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. Its regulation is upregulated by interferon gamma. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune -like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc. (2). Recently, two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI (1). Alternate Names: BLyS, Thank, TALL-1.
UniProt Q9Y275
Research Area Apoptosis/Necrosis
Application Notes Western blot: 0.5 - 2.0 ug/ml. Recommended positive control: mouse testis, thymus, or spleen, or HL60. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2 % gelatin, 0.05 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (C-Term), (AA 254-269) antibody Western blot analysis of BAFF/BLyS in mouse and human cell lysates. Lane A: mouse testis, Lane B: mouse thymus, Lane C: mouse spleen, and Lane D: HL-60 cells (human).
General Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Mukhopadhyay, Ni, Zhai et al.: "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15978-81, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Mackay, Woodcock, Lawton et al.: "Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations." in: The Journal of experimental medicine, Vol. 190, Issue 11, pp. 1697-710, 2000 (PubMed).

Hosts (79), (57), (27), (7)
Reactivities (156), (44), (42), (12), (12)
Applications (114), (81), (44), (29), (22), (16), (10), (9), (7), (7), (4), (4), (4), (2), (1), (1)
Conjugates (13), (11), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (6), (6), (5), (4), (2), (1), (1), (1)
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