Caspase 12 (CASP12) (AA 2-17) antibody

Details for Product No. ABIN123303
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Antigen
Epitope
AA 2-17
(12), (10), (8), (8), (7), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(96), (93), (73)
Host
Rabbit
(120), (9), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(110), (52), (51), (34), (20), (13), (11), (11), (8), (7), (5), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123303
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Immunogen Synthetic peptide corresponding to amino acids 2-17 of murine Caspase-12
Purification Protein G affinity chromatography
Alternative Name Caspase-12
Background Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. A newly discovered member of this family Caspase-12, is localized to the endoplasmic reticulum (ER) but not to the cytoplasm or mitochondrion. In the ER it is associated with proteins that are involved in Alzheimer disease.
UniProt Q6UXS9
Research Area Apoptosis/Necrosis
Application Notes Western blotting: 0.5-1 ug/ml. Recommended positive control: mouse spleen. Immunohistochemistry on paraffin embedded tissues: 10 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, pH 7.2, with 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 12 (CASP12) (AA 2-17) antibody Western blot analysis for Caspase-12 using ABIN123303 at 1 ug/ml against 15 ug of mouse spleen cell lysate
General Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

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