Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (C-Term), (AA 505-521) antibody

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Antigen
Synonyms MCH4, ALPS2, FLICE2, xCaspase-10, alps2, caspace-10, caspase-10, flice2, mch4, xCaspace-10
Epitope
C-Term, AA 505-521
(24), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(113), (16), (15), (1), (1), (1)
Host
Rabbit
(102), (8), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(90), (43), (23), (21), (19), (10), (10), (6), (4), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN123304
Quantity 0.1 mg
Price
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Immunogen Peptide corresponding to amino acids 505 to 521 at the C-terminus of human FLICE2 (1)
Purification Purified
Alternative Name Caspase-10
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 (1,2) and renamed as Caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis (1). Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death (3). Caspase-10 is expressed in many tissues and cell lines (1,2).
UniProt Q92851
Research Area Apoptosis/Necrosis
Application Notes Western blot at 2-4 ug/ml dilution. Recommended Positive Control: HeLa. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (C-Term), (AA 505-521) antibody Western blot analysis of 15 ug of total cell lysate from HeLa cells with anti-Caspase-10 at 4 ug/ml
General Fernandes-Alnemri, Armstrong, Krebs et al.: "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 15, pp. 7464-9, 1996 (PubMed).

Vincenz, Dixit: "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling." in: The Journal of biological chemistry, Vol. 272, Issue 10, pp. 6578-83, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Hosts (102), (8), (2), (1)
Reactivities (113), (16), (15), (1), (1), (1)
Applications (90), (43), (23), (21), (19), (10), (10), (6), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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