C-C Chemokine Receptor Type 1 (CCR1) (AA 339-350) antibody

Details for Product No. ABIN123307
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AA 339-350
(24), (14), (11), (5), (3), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(69), (15), (2), (2), (1)
(51), (10), (8), (7), (2)
(7), (4), (4), (2), (2), (2)
Western Blotting (WB), Flow Cytometry (FACS)
(54), (34), (31), (25), (15), (4), (4), (3), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN123307
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Immunogen Synthetic peptide corresponding to amino acids 339-350 of human CCR1 protein AA Sequence:VSSTSPSTGEHEC
Isotype IgG
Purification Protein G Chromatography.
Alternative Name CD191 / CCR1
Background Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5, 6). Alternate Names: CD191.
UniProt P32246
Research Area Chemokines, Receptors
Application Notes Western blotting: 1-3 ug/ml. Recommended Positive Control: A375 (a band of approx. size 42 kD should be detected). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% Gelatin and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-C-C Chemokine Receptor Type 1 (CCR1) (AA 339-350) antibody Surface staining of mouse primary epidermal cells (B-6 mice, 30wks) with CL 11-PE, CD11c PE-Cy5, and CCR1 (ABIN123307) with CY5 goat anti rabbit secondary. Image 2: CD11c+ CL II+ cells (Langerans), stained with rabbit isotype control (shaded histogram) were analyzed for CCR1 at 5 µl (blue histogram) and 10 µl (green histogram). Data kindly provided by Corey Parlet, University of Iowa.
anti-C-C Chemokine Receptor Type 1 (CCR1) (AA 339-350) antibody (2) Western blot analysis of 10 ug of total cell lysate from A357 cells with ABIN123307 at 2 ug/ml dilution.
General Broxmeyer, Cooper, Hangoc et al.: "Dominant myelopoietic effector functions mediated by chemokine receptor CCR1." in: The Journal of experimental medicine, Vol. 189, Issue 12, pp. 1987-92, 1999 (PubMed).

Gao, Wynn, Chang et al.: "Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1." in: The Journal of experimental medicine, Vol. 185, Issue 11, pp. 1959-68, 1997 (PubMed).

Gao, Sen, Kitaura et al.: "Identification of a mouse eosinophil receptor for the CC chemokine eotaxin." in: Biochemical and biophysical research communications, Vol. 223, Issue 3, pp. 679-84, 1996 (PubMed).

Neote, DiGregorio, Mak et al.: "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor." in: Cell, Vol. 72, Issue 3, pp. 415-25, 1993 (PubMed).

Gao, Murphy: "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." in: The Journal of biological chemistry, Vol. 270, Issue 29, pp. 17494-501, 1995 (PubMed).

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