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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Chemokine (C-C Motif) Receptor 1 (CCR1) antibody
|Synonyms||CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1|
Human, Mouse (Murine)
Alternatives Western Blotting (WB), Flow Cytometry (FACS)
|5 references available|
|Quantity||0.1 mg (0.5 mg/ml) (Variants)|
|Price||308.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||CD191 / CCR1|
|Immunogen||Synthetic peptide corresponding to amino acids 339-350 of human CCR1 protein AA Sequence:VSSTSPSTGEHEC|
|Cross-Reactivity||Human, Mouse (Murine)|
|Description||Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5, 6). Alternate Names: CD191.|
|Application Notes||Western blotting: 1-3 ug/ml. Recommended Positive Control: A375 (a band of approx. size 42 kD should be detected). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS containing 0.0 2% sodium azide|
|Storage||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.|
|Research Area||Chemokines, Receptors|
|Restrictions||For Research Use only|
Gao, Murphy: "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." in: The Journal of biological chemistry, Vol. 270, Issue 29, pp. 17494-501, 1995 (PubMed).
Neote, DiGregorio, Mak et al.: "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor." in: Cell, Vol. 72, Issue 3, pp. 415-25, 1993 (PubMed).
Gao, Sen, Kitaura et al.: "Identification of a mouse eosinophil receptor for the CC chemokine eotaxin." in: Biochemical and biophysical research communications, Vol. 223, Issue 3, pp. 679-84, 1996 (PubMed).
Gao, Wynn, Chang et al.: "Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1." in: The Journal of experimental medicine, Vol. 185, Issue 11, pp. 1959-68, 1997 (PubMed).
Broxmeyer, Cooper, Hangoc et al.: "Dominant myelopoietic effector functions mediated by chemokine receptor CCR1." in: The Journal of experimental medicine, Vol. 189, Issue 12, pp. 1987-92, 1999 (PubMed).
|Hosts||Rabbit (37), Mouse (6), Goat (2)|
|Reactivities||Human (43), Mouse (Murine) (23), Rat (Rattus) (20), Monkey (2), Cow (Bovine) (1)|
|Applications||Western Blotting (WB) (20), Immunofluorescence (IF) (17), ELISA (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Flow Cytometry (FACS) (6), Immunohistochemistry (IHC) (4), Immunocytochemistry (ICC) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (2), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)|
|Conjugates||PE (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||N-Term (3), AA 7-24 (2), C-Term (1), Extracellular Domain (1)|