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Details for Product No. ABIN123309

Chemokine (C-C Motif) Receptor 3 (CCR3) antibody

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Antigen
Synonyms CC-CKR-3, CD193, CKR3, CMKBR3, Cmkbr3, CC-CKR3, Cmkbr1l2
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN123309
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Synthetic peptide of human CCR3 protein
Purification Protein G Chromatography
Alternative Name CD193 / CCR3
Background Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR3 (eotaxin receptor), is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin, including RANTES, monocyte chemotactic protein (MCP)-2, MCP-3, and MCP-4 (2,3). CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, and inhibited infection by these isolates (4).
UniProt P51677
Research Area Chemokines, Receptors, CD Antigens
Application Notes Western blot: 1 - 3 ug/ml. Recommended Positive Control: Daudi (a 45 kDa band should be observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Choe, Farzan, Sun et al.: "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates." in: Cell, Vol. 85, Issue 7, pp. 1135-48, 1996 (PubMed).

Sallusto, Mackay, Lanzavecchia: "Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells." in: Science (New York, N.Y.), Vol. 277, Issue 5334, pp. 2005-7, 1997 (PubMed).

Alternatives for antigen "Chemokine (C-C Motif) Receptor 3 (CCR3)", type "Antibodies"
Hosts (75), (16), (8), (3)
Reactivities (94), (33), (32), (13), (12)
Applications (55), (34), (30), (21), (20), (10), (9), (5), (1), (1), (1), (1)
Conjugates (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (16), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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