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Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

Antigen

Chemokine (C-C Motif) Receptor 4 (CCR4)
Synonyms CKR4, K5-5, CD194, CMKBR4, ChemR13, CC-CKR-4, MGC88293, HGCN:14099
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
4 references available
Catalog no. ABIN123310
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 297.00 $   Plus shipping costs $45.00
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anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

Additional Information
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Alternative name CD194 / CCR4
UniProt P51679
Immunogen Synthetic peptide of human CCR4 protein. AA Sequence: IYSADTPSSSYTQSTC
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up- regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Alternate Names: CMKBR4, C-C CKR-4, CC-CKR-4, CCR-4, K5-5, C-C Chemokine Receptor 4, Chemokine (CC motif) Receptor 4.

Application Details
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Application Notes Western blot (1-2 ug/ml). Recommended Positive Control: Daudi (a band with an approx. size 42 kDa should be detected). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
Purification Purified
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Research Area Chemokines, Receptors
Restrictions For Research Use only

Publications
Application Details Images Alternatives Variants back to top

Gao, Murphy: "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." in: The Journal of biological chemistry, Vol. 270, Issue 29, pp. 17494-501, 1995 (PubMed).

Neote, DiGregorio, Mak et al.: "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor." in: Cell, Vol. 72, Issue 3, pp. 415-25, 1993 (PubMed).

Murphy: "Chemokine receptors: structure, function and role in microbial pathogenesis." in: Cytokine & growth factor reviews, Vol. 7, Issue 1, pp. 47-64, 1997 (PubMed).

Broxmeyer, Cooper, Hangoc et al.: "Dominant myelopoietic effector functions mediated by chemokine receptor CCR1." in: The Journal of experimental medicine, Vol. 189, Issue 12, pp. 1987-92, 1999 (PubMed).