Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

Details for Product No. ABIN123310
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Human, Mouse (Murine), Rat (Rattus)
(72), (36), (24), (5), (3), (1)
(71), (11), (4), (1)
(4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(50), (41), (25), (18), (12), (10), (7), (6), (6), (4), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN123310
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Immunogen Synthetic peptide of human CCR4 protein. AA Sequence: IYSADTPSSSYTQSTC
Purification Protein G Chromatography.
Alternative Name CD194 / CCR4
Background CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up- regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Alternate Names: CMKBR4, C-C CKR-4, CC-CKR-4, CCR-4, K5-5, C-C Chemokine Receptor 4, Chemokine (CC motif) Receptor 4.
UniProt P51679
Research Area Chemokines, Receptors
Application Notes Western blot (1-2 ug/ml). Recommended Positive Control: Daudi (a band with an approx. size 42 kDa should be detected). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody Western blot analysis of CCR4 in A) Daudi and B) NIH 3T3 cell lysate using ABIN123310 at 1 µg/ml.
General Broxmeyer, Cooper, Hangoc et al.: "Dominant myelopoietic effector functions mediated by chemokine receptor CCR1." in: The Journal of experimental medicine, Vol. 189, Issue 12, pp. 1987-92, 1999 (PubMed).

Murphy: "Chemokine receptors: structure, function and role in microbial pathogenesis." in: Cytokine & growth factor reviews, Vol. 7, Issue 1, pp. 47-64, 1997 (PubMed).

Neote, DiGregorio, Mak et al.: "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor." in: Cell, Vol. 72, Issue 3, pp. 415-25, 1993 (PubMed).

Gao, Murphy: "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." in: The Journal of biological chemistry, Vol. 270, Issue 29, pp. 17494-501, 1995 (PubMed).

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