Death-Domain Associated Protein (DAXX) (C-Term), (AA 722-740) antibody

Details for Product No. ABIN123326
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Antigen
Epitope
C-Term, AA 722-740
(24), (19), (18), (17), (13), (13), (11), (6), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine)
(204), (65), (52), (48), (37), (24), (5), (4)
Host
Rabbit
(175), (34)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
Western Blotting (WB)
(142), (65), (60), (41), (35), (29), (24), (11), (10), (7), (6), (6), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123326
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Immunogen Peptide corresponding to amino acid 722 to 740 at C-terminus of human Daxx (1,2)
Purification Protein G chromatography
Alternative Name DAXX
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (1,2). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways (1,2).
UniProt Q9UER7
Application Notes Western blot: 1/500 - 1/1000. Recommended positive control: HeLa. A 120 kDa major band should be observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Death-Domain Associated Protein (DAXX) (C-Term), (AA 722-740) antibody Western blot analysis of 10 ug of total cell lysate from HeLa cells with anti-Daxx (CT) at 1:1000 dilution.
General Kiriakidou, Driscoll, Lopez-Guisa et al.: "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region." in: DNA and cell biology, Vol. 16, Issue 11, pp. 1289-98, 1998 (PubMed).

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